Ribonuclease P by Fenyong Liu (English) Hardcover Book

Description: Ribonuclease P by Fenyong Liu, Sidney Altman This association implied these parts of the tRNA, namely the D loop containing residue 15 and the 5 end of the T stem-adjoining residue 48, folded on one another in a tertiary structure shared by different tRNAs. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D structure of yeast phenylalanine tRNA, a structure that is generally common to tRNAs, due in part to several conserved, novel three-way nucleotide interactions. ) Concurrently, Michael Levitt, a Ph. D. student of Francis, was visually scrutinizing the cloverleaf secondary structure of the 14 tRNA sequences known at the time. Levitt was searching for nucleotide covariation in different parts of the molecules that were conserved in the 14 sequences known at the time. He identified a possible covariation of an apparent Watson-Crick pairing type between the residues at position 15 from the 5 end of the tRNA and residue 48. This association implied these parts of the tRNA, namely the D loop containing residue 15 and the 5 end of the T stem-adjoining residue 48, folded on one another in a tertiary structure shared by different tRNAs. Notes Will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis Back Cover Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry. Table of Contents History of RNase P and Overview of Its Catalytic Activity.- The Evolution of RNase P and Its RNA.- Over a Decade of Bacterial Ribonuclease P Modeling.- Structural Studies of Ribonuclease P.- Folding of Bacterial RNase P RNA.- Kinetic Mechanism of Bacterial RNase P.- Roles of Metal Ions in RNase P Catalysis.- Challenges in RNase P Substrate Recognition: Considering the Biological Context.- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives.- Eukaryote RNase P and RNase MRP.- RNase P from Organelles.- Human RNase P and Transcription.- RNase P as a Drug Target.- Ribonuclease P as a Tool. Long Description The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D structure of yeast phenylalanine tRNA, a structure that is generally common to tRNAs, due in part to several conserved, novel three-way nucleotide interactions. ) Concurrently, Michael Levitt, a Ph. D. student of Francis, was visually scrutinizing the cloverleaf secondary structure of the 14 tRNA sequences known at the time. Levitt was searching for nucleotide covariation in different parts of the molecules that were conserved in the 14 sequences known at the time. He identified a possible covariation of an apparent Watson-Crick pairing type between the residues at position 15 from the 5 end of the tRNA and residue 48. This association implied these parts of the tRNA, namely the D loop containing residue 15 and the 5 end of the T stem-adjoining residue 48, folded on one another in a tertiary structure shared by different tRNAs. Feature Will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis Details ISBN1441911413 Series Protein Reviews Language English ISBN-10 1441911413 ISBN-13 9781441911414 Media Book Format Hardcover Series Number 10 Year 2009 DEWEY 572.88 Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Edited by Sidney Altman Birth 1964 Short Title RIBONUCLEASE P 2010/E Pages 283 DOI 10.1007/978-1-4419-1142-1 AU Release Date 2009-12-23 NZ Release Date 2009-12-23 US Release Date 2009-12-23 UK Release Date 2009-12-23 Author Sidney Altman Publisher Springer-Verlag New York Inc. Edition Description 2010 ed. Edition 2010th Publication Date 2009-12-23 Alternative 9781461425731 Audience Professional & Vocational Illustrations 23 Illustrations, color; 30 Illustrations, black and white; XVI, 283 p. 53 illus., 23 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96315171;

Price: 317.54 AUD

Location: Melbourne

End Time: 2025-01-06T10:15:58.000Z

Shipping Cost: 17.09 AUD