Recent Advances in Glucocorticoid Receptor Action

Description: Recent Advances in Glucocorticoid Receptor Action Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): A. Cato, H. Schaecke, K. Asadullah Format: Paperback Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN-13: 9783662046623, 978-3662046623 Synopsis Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar- macological concentrations for the suppression of clinical manifesta- tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im- portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu- taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef- fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos- metic ([url] telangiectasias, hypertrichosis) to seriously disabling ([url] induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders ([url] gastric haemorrhage). These adverse effects of GCs se- riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.

Price: 103.86 GBP

Location: Aldershot

End Time: 2024-01-16T09:13:54.000Z

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