Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research

Description: Modern Molecular Biology: by Srinivasan Yegnasubramanian, William B. Isaacs This volume provides an overview of modern molecular biological approaches to unbiased discovery in cancer research. It examines advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers.The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics. Back Cover A convergence of advancements in molecular biology, engineering, computer science, biostatistics and other disciplines has made possible the development of technologies facilitating the massively parallel investigation of the complex biological phenomena driving cancer initiation and progression. Such technologies include DNA microarrays, next generation sequencing, proteomics technologies, and tissue microarrays.In order to properly harness these technologies to imaginatively decipher these complex biological processes, scientists must have an understanding of the underlying technology, be able to adapt these technologies with molecular biology lab approaches, and then be poised to efficiently process and interpret the extremely high dimensional and complex data sets that are generated by these technologies. The primary purpose of this volume is to help bridge the gap between molecular biologists and cancer researchers and the bioinformatics and computational biology researchers by providing an overview of these technologies to those that are not yet familiar with them. Table of Contents Genome-Scale Analysis of Data from High-Throughput Technologies.- Analysis of Inherited and Acquired Genetic Variation.- Examining DNA–Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis.- Genome-Wide DNA Methylation Analysis in Cancer Research.- Use of Expression Microarrays in Cancer Research.- Signal Sequencing for Gene Expression Profiling.- Mass Spectrometry Based Proteomics in Cancer Research.- Tissue Microarrays in Cancer Research. Long Description Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics. Feature The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed These include the strategies employed in modern genomics, gene expression analysis, and proteomics Details ISBN146142657X Short Title MODERN MOLECULAR BIOLOGY 2010/ Series Applied Bioinformatics and Biostatistics in Cancer Research Language English ISBN-10 146142657X ISBN-13 9781461426578 Media Book Format Paperback Year 2012 Publication Date 2012-11-05 Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Edited by William B. Isaacs Subtitle Approaches for Unbiased Discovery in Cancer Research Pages 192 Edition 2010th AU Release Date 2012-11-05 NZ Release Date 2012-11-05 US Release Date 2012-11-05 UK Release Date 2012-11-05 Author William B. Isaacs Publisher Springer-Verlag New York Inc. Edition Description 2010 ed. Alternative 9780387697444 DEWEY 616.9 Audience Professional & Vocational Illustrations XII, 192 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96371287;

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