Marburg- and Ebolaviruses: From Ecosystems to Molecules by Lisa L. Hensley (Engl

Description: Marburg- and Ebolaviruses by Lisa L. Hensley, Jonathan S. Towner, Elke MÜhlberger This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike. FORMAT Paperback LANGUAGE English CONDITION Brand New Back Cover This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike. Author Biography Elke MÜhlbergerBoston University School of Medicine Boston, MA, USAe-mail: Lisa L. HensleyNational Institutes of HealthNIAIDFrederick, MD, USAe-mail: Jonathan S. TownerCenters for Disease Control & PreventionAtlanta, GA, USAe-mail: Table of Contents Filovirus Research: How it began.- Ecology of Filoviruses.- West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis.- Clinical Management of Ebola Virus Disease Patients in Low Resource Settings.- Clinical Management of Patients with Ebola Virus Disease in High Resource Settings.- Ebola Virus Disease in Humans: Pathophysiology and Immunity.- Nonhuman Primate Models of Ebola Virus Disease.- Small Animal Models for Studying Filovirus Pathogenesis.- Accelerating Vaccine Development during the West African Ebola Virus Disease Outbreak.- Therapeutics against Filovirus Infection.- Filovirus Strategies to Escape Antiviral Responses.- Mechanisms of Filovirus Entry.- Inside the Cell: Assembly of Filoviruses.- Filovirus Structural Biology: The Molecules in the Machine.- Reverse Genetics of Filoviruses.- Guide to the Correct Use of Filoviral Nomenclature. Feature Summarizes the latest studies on intracellular events during filovirus infection Focuses on mechanisms of viral entry and receptor binding, assembly of the viral particles inside the cell, and the use of reverse genetic systems Explains recent advances in our understnding of filovirus disease, pathology in the NHP model, and the development of new small animal models to study filovirus infectionn Description for Sales People Summarizes the latest studies on intracellular events during filovirus infection Focuses on mechanisms of viral entry and receptor binding, assembly of the viral particles inside the cell, and the use of reverse genetic systems Explains recent advances in our understnding of filovirus disease, pathology in the NHP model, and the development of new small animal models to study filovirus infectionn Details ISBN3319886894 Pages 460 Year 2019 ISBN-10 3319886894 ISBN-13 9783319886893 Format Paperback Imprint Springer International Publishing AG Subtitle From Ecosystems to Molecules Place of Publication Cham Country of Publication Switzerland Edited by Elke MÜhlberger Illustrations X, 460 p. DEWEY 614.588 Publication Date 2019-06-06 Short Title Marburg- and Ebolaviruses Language English Series Number 411 UK Release Date 2019-06-06 Author Elke MÜhlberger Publisher Springer International Publishing AG Edition Description Softcover reprint of the original 1st ed. 2017 Series Current Topics in Microbiology and Immunology Alternative 9783319689463 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131033144;

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