Guanidine Hydrochloride 50g+

Description: Guanidine Hydrochloride 50g+ Guanidinium chloride or guanidine hydrochloride, usually abbreviated GdmCl and sometimes GdnHCl or GuHCl, is the hydrochloride salt of guanidine. Guanidinium chloride is a weak acid with a pKa of 13.6. The reason that it is such a weak acid is the complete delocalisation of the positive charge through 3 nitrogen atoms (plus a little bit positive charge on carbon). However, some stronger bases can deprotonate it, such as sodium hydroxide. Guanidinium chloride is a strong chaotrope and one of the strongest denaturants used in physiochemical studies of protein folding. It also has the ability to decrease enzyme activity and increase the solubility of hydrophobic molecules. At high concentrations of guanidinium chloride (e.g., 6 M), proteins lose their ordered structure, and they tend to become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, guanidinium chloride has been shown to "cure" prion positive yeast cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative phenotype). This is the result of inhibition of the Hsp104 chaperone protein known to play an important role in prion fiber fragmentation and propagation. It is used in the recovery of organic materials in fossilized dinosaur bones. You will receive 1- 50g bag of Guanidine Hydrochloride that is sealed shut. That bag will be bagged again and bubble wrapped and shipped in a blue bubble wrap padded envelope and shipped using USPS Ground Advantage Mail with tracking. Watch for the blue envelope in your mailbox.

Price: 13.95 USD

Location: Salt Lick, Kentucky

End Time: 2024-11-11T00:44:38.000Z

Shipping Cost: 4.75 USD