Description: Flipons by Alan Herbert Estimated delivery 3-12 business days Format Hardcover Condition Brand New Description Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. Publisher Description Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipons exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enable the assembly of cellular machines. The intransitive logic involved enhances the chance of an individual surviving a constantly changing environment.Key FeaturesCauses us to rethink how information is encoded in the genomeChanges our understanding of how our genome evolved and how we protect ourselves against viruses and cancers while sparing normal cellsShows that high energy forms of DNA, such as left-handed DNA do exist inside the cellAccessible to those in academia and the general public, and speaks to the next generation, encouraging them to find their own path in scientific discoveryThe Open Access version of this book, available at , has been made available under a Creative Commons Attribution-Non-Commercial-No Derivative License (CC-BY-NC-ND) 4.0 license. Author Biography Dr. Alan Herberts career spans both academia and industry. He is Head of Discovery at InsideOutBio and has published in high profile journals. His work on left-handed Z-DNA and Z-RNA has proven that besides the right-handed DNA double helix that Watson and Crick first described, higher energy forms of DNA and RNA are used in the cell to regulate many important biological functions including defenses against viruses and cancer and to regulate the readout of information from the genome. His publications include one providing the first genetic evidence for the biological relevance of the Z-DNA/Z-RNA conformation. This work started with his discovery at MIT of the Zα family of proteins that recognize a form of left-handed DNA called Z-DNA. During this time, Dr. Herbert has had many fruitful collaborations with scientists worldwide who have made great contributions to the work. These discoveries led to the therapeutic targeting of ZBP1lated to develop a new therapy for the treatment of solid tumors. In other endeavors, he pioneered the use of Genome Wide Association Studies at Boston University and contributed to the development of new drug programs at Merck. Dr. Herbert has also helped expand understanding of the role of the alternative DNA structures encoded by genetic elements called flipons in evolution. He has also detailed mechanisms by which the interactions between small noncoding RNAs and flipons regulate the sequence-specific read of genes during embryonic development. Details ISBN 1032732962 ISBN-13 9781032732961 Title Flipons Author Alan Herbert Format Hardcover Year 2024 Pages 209 Publisher Taylor & Francis Ltd GE_Item_ID:159134184; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. 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Price: 174.55 USD
Location: Fairfield, Ohio
End Time: 2024-11-15T03:27:00.000Z
Shipping Cost: 0 USD
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Item Specifics
Restocking Fee: No
Return shipping will be paid by: Buyer
All returns accepted: Returns Accepted
Item must be returned within: 30 Days
Refund will be given as: Money Back
ISBN-13: 9781032732961
Type: NA
Publication Name: NA
Book Title: Flipons : the Discovery of Z-D N A and Soft-Wired Genomes
Number of Pages: 210 Pages
Language: English
Publisher: CRC Press LLC
Topic: Life Sciences / Molecular Biology, Microbiology, Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Biochemistry
Publication Year: 2024
Illustrator: Yes
Genre: Science, Medical
Author: Alan Herbert
Item Length: 9.2 in
Item Width: 6.1 in
Format: Hardcover
