Description: Clinical Trial Design : Bayesian and Frequentist Adaptive Methods, Hardcover by Yin, Guosheng, ISBN 0470581719, ISBN-13 9780470581711, Like New Used, Free shipping in the US A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, th establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout th is freely available on th's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. Th also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
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Book Title: Clinical Trial Design : Bayesian and Frequentist Adaptive Methods
Number of Pages: 368 Pages
Publication Name: Clinical Trial Design : Bayesian and Frequentist Adaptive Methods
Language: English
Publisher: Wiley & Sons, Incorporated, John
Publication Year: 2012
Subject: Clinical Medicine
Item Height: 0.9 in
Type: Textbook
Item Weight: 22.8 Oz
Subject Area: Medical
Author: Guosheng Yin
Item Length: 9.6 in
Item Width: 6.4 in
Format: Hardcover
