Description: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Amita Kashyap, D. Bujamma, Naresh Babu M Format: Paperback Publisher: Springer Verlag, Singapore, Singapore Imprint: Springer Verlag, Singapore ISBN-13: 9789814585071, 978-9814585071 Synopsis Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
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Book Title: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto...
Subject Area: Health Education
Item Height: 235 mm
Item Width: 155 mm
Series: Springerbriefs in Applied Sciences and Technology
Author: Naresh Babu M, Amita Kashyap, D. Bujamma
Publication Name: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Format: Paperback
Language: English
Publisher: Springer Verlag, Singapore
Subject: Medicine, Engineering & Technology, Computer Science
Publication Year: 2014
Type: Textbook
Item Weight: 1358 g
Number of Pages: 72 Pages
