Arachidonic Acid Metabolism and Tumor Promotion by Susan M. Fischer (English) Ha

Description: Arachidonic Acid Metabolism and Tumor Promotion by Susan M. Fischer, Thomas J. Slaga Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary carÂ cinoma. Since that time, the concept that arachidonic acid metabolites may be inÂ volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respecÂ arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prostaÂ glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of prosÂ taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autoc FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec- arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate.This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids. Author Biography SEYMOUR FISHER, PhD, is Professor of Psychology at the State University of New York Health Science Center in Syracuse, New York. Dr. Fisher received his doctorate in clinical psychology from the University of Chicago. His other books include Development and Structure of the Body Image, Sexual Images of the Self, and The Psychology of Adaptation to Absurdity. ROGER P. GREENBERG, PhD, is Professor and Head of the Division of Clinical Psychology in the Department of Psychiatry at the State University of New York. He also has an active private practice. Dr. Greenberg received his doctorate in c Table of Contents 1. Arachidonic Acid Metabolism in the Skin.- 2. Arachidonic Acid Metabolism and Tumor Promotion.- 3. Prostaglandins, Epidermal Hyperplasia and Skin Tumor Promotion.- 4. Effects of Phorbol Esters on Phospholipid Metabolism in Vitro.- 5. Tumor Promoting Phorbol Esters May Affect Cell Membrane Signal Transmission by Protein Kinase.- 6. Active Oxygen and Promotion.- 7. Possible Involvement of Arachidonate Products in Tumor Promoter Inhibition of Cell-Cell Communication.- 8. Proteases and Cyclic Nucleotides.- Perspectives. Long Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car Details ISBN0898387248 Year 1985 ISBN-10 0898387248 ISBN-13 9780898387247 Format Hardcover Imprint Kluwer Academic Publishers Place of Publication Dordrecht Edited by Susan M. Fischer DEWEY 616.994071 Author Thomas J. Slaga Media Book Short Title ARACHIDONIC ACID METABOLISM & Language English Publisher Kluwer Academic Publishers Country of Publication United States Publication Date 1985-04-30 Pages 264 Illustrations VIII, 264 p. DOI 10.1007/b113243 Series Number 3 AU Release Date 1985-04-30 NZ Release Date 1985-04-30 US Release Date 1985-04-30 UK Release Date 1985-04-30 Edition Description 1985 ed. Series Prostaglandins, Leukotrienes, and Cancer Edition 1985th Alternative 9781461296317 Audience Postgraduate, Research & Scholarly We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96236010;

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