Arachidonic Acid Metabolism and Tumor Promotion by Susan M. Fischer (English) Ha

Description: Arachidonic Acid Metabolism and Tumor Promotion by Susan M. Fischer, Thomas J. Slaga Estimated delivery 3-12 business days Format Hardcover Condition Brand New Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary carÂ cinoma. Since that time, the concept that arachidonic acid metabolites may be inÂ volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respecÂ arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prostaÂ glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of prosÂ taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autoc Publisher Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec- arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate.This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids. Author Biography SEYMOUR FISHER, PhD, is Professor of Psychology at the State University of New York Health Science Center in Syracuse, New York. Dr. Fisher received his doctorate in clinical psychology from the University of Chicago. His other books include Development and Structure of the Body Image, Sexual Images of the Self, and The Psychology of Adaptation to Absurdity. ROGER P. GREENBERG, PhD, is Professor and Head of the Division of Clinical Psychology in the Department of Psychiatry at the State University of New York. He also has an active private practice. Dr. Greenberg received his doctorate in c Details ISBN 0898387248 ISBN-13 9780898387247 Title Arachidonic Acid Metabolism and Tumor Promotion Author Susan M. Fischer, Thomas J. Slaga Format Hardcover Year 1985 Pages 264 Edition 1985th Publisher Kluwer Academic Publishers GE_Item_ID:137806840; About Us Grand Eagle Retail is the ideal place for all your shopping needs! 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