Arachidonic Acid Metabolism and Tumor Initiation by Lawrence J. Marnett (English

Description: Arachidonic Acid Metabolism and Tumor Initiation by Lawrence J. Marnett Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary carÂ cinoma. Since that time, the concept that arachidonic acid metabolites may be inÂ volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respecÂ tively. Cyclooxygenase products consist of diverse products such as prostaÂ glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelssons extensive study of the metabolism of prosÂ taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autoc FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate.This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelssons extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids. Table of Contents 1. Metabolism and the "Initiation" of Tumors by Chemicals.- 2. Arachidonic Acid Metabolism and Tumor Initiation.- 3. Arachidonic Acid-Dependent Metabolism of Chemical Carcinogens and Toxicants.- 4. Prostaglandin Synthase-Dependent Cooxidation and Aromatic Amine Carcinogenesis.- 5. Involvement of Prostaglandin Synthase in the Metabolic Activation of Acetaminophen and Phenacetin. Long Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car Details ISBN0898387299 Year 1985 ISBN-10 0898387299 ISBN-13 9780898387292 Format Hardcover Imprint Kluwer Academic Publishers Place of Publication Dordrecht Edited by Lawrence J. Marnett DEWEY 616.994071 Affiliation Vanderbilt University School of Medicine, Nashville, TN, USA Author Lawrence J. Marnett Media Book Short Title ARACHIDONIC ACID METABOLISM & Series Prostaglandins, Leukotrienes, and Cancer Language English Series Number 2 Publisher Kluwer Academic Publishers Country of Publication United States Publication Date 1985-04-30 Pages 200 Edition 1985th Illustrations XIV, 200 p. DOI 10.1007/b113246 AU Release Date 1985-04-30 NZ Release Date 1985-04-30 US Release Date 1985-04-30 UK Release Date 1985-04-30 Edition Description 1985 ed. Alternative 9781461296348 Audience Postgraduate, Research & Scholarly We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96236044;

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