Description: Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcohol abuse significantly increase the risk of a wide range of serious lung infections. Many clinicians involved in the primary treatment of alcohol use disorders, such as addiction psychiatrists, will find this text of interest as it will expand their understanding of the health consequences of alcohol use disorders. In parallel, clinicians who specialize in pulmonary and/or critical care medicine will have a unique resource that provides a comprehensive review of the pathophysiology of alcohol-related lung disorders and insights into evolving therapeutic options in these vulnerable individuals. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach fills a gap in the literature and presents the evolving clinical research that may soon lead to novel therapies that can improve lung health in individuals with alcohol use disorders and co-existing conditions such as HIV infection. Section I: The Epidemiology of Alcohol Use and Lung Health Chapter 1 A Brief History of Alcohol Use and Abuse in Human History David M. Guidot, MD, Ashish J. Mehta, MD, MSc Chapter 2 Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations David M. Guidot, MD, Ashish J. Mehta, MD, MSc Chapter 3 Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research Karen Drexler, M.D Chapter 4 The Epidemiology of Alcohol Abuse and Pneumonia Kyle I. Happel, M.D Chapter 5 The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome Brendan J. Clark, MD and Ellen L. Burnham, MD, MS Section II: The Pathophysiology of the 'Alcoholic Lung' Chapter 6 Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways Todd A. Wyatt, PhD and Joseph H. Sisson, MD Chapter 7 Alcohol and the Alveolar Macrophage Samantha M. Yeligar, MS, PhD; Yan Liang, PhD; Lou Ann S. Brown, PhD Chapter 8 Alcohol and the Alveolar Epithelium Samuel Molina, Ph.D. and Michael Koval, Ph.D. Chapter 9 Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion Samantha M. Yeligar, MS, PhD; Yan Liang, PhD; and Lou Ann S. Brown, PhD Chapter 10 Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments Kevin L. Legge, PhD* and Thomas J. Waldschmidt, PhD Chapter 11 Alcohol Impairment of Granulocyte Function During Lung Infection Gregory J. Bagby, Ph.D., Kyle Happel, MD, J Nicholas Melvan, MD, Ph.D Chapter 12: Disruption in the Dynamic Balance Between Transforming Growth Factor-ß and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function David M. Guidot, MD, Ashish J. Mehta, MD, MSc Chapter 13 Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung Ashish J. Mehta, MD, MSc, David M. Guidot, MD Section III: Special Circumstances Chapter 14 The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient Katharina Chalk, MD Claudia Spies, MD Chapter 15 Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung Sushma K. Cribbs, MD, David Rimland, MD Chapter 16 Maternal Alcohol Use and the Neonate Theresa W. Gauthier, MD, Danielle Giliberti, MD, PhD Sowmya S. Mohan, MD, Juna Konomi, BA, Lou Ann S. Brown, PhD
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EAN: 9781493945009
UPC: 9781493945009
ISBN: 9781493945009
MPN: N/A
Item Length: 23.4 cm
Item Height: 235 mm
Item Width: 155 mm
Author: David M. Guidot, Ashish J. Mehta
Publication Name: Alcohol Use Disorders and the Lung: a Clinical and Pathophysiological Approach
Format: Paperback
Language: English
Publisher: Humana Press Inc.
Subject: Medicine, Psychology, Biology
Publication Year: 2016
Type: Textbook
Item Weight: 4044 g
Number of Pages: 252 Pages